Maternal separation with early weaning: a novel mouse model of early life neglect
نویسندگان
چکیده
منابع مشابه
Maternal control of early mouse development.
The hiatus between oocyte and embryonic gene transcription dictates a role for stored maternal factors in early mammalian development. Encoded by maternal-effect genes, these factors accumulate during oogenesis and enable the activation of the embryonic genome, the subsequent cleavage stages of embryogenesis and the initial establishment of embryonic cell lineages. Recent studies in mice have y...
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The early life of most mammals is spent in close contact with the mother, and for the neonate, early maternal separation is a traumatic event that, depending on various conditions, may shape its behavioral and neurochemical phenotype in adulthood. Studies on rodents demonstrated that a very brief separation followed by increased maternal care may positively affect the development of the offspri...
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http://www.aasp.org/shap/issues/v5n5/index.html he earliest efforts to use early weaning and segregation technologies to obtain pathogen-free piglets were attempted in the early 1980s.1 Initially, the strategy called for weaning pigs at 5–10 days of age and relying on medication.1,2 Later studies suggested that early weaning without medication could also reduce, but not eliminate, the impact of...
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Early weaning is a management practice that reduces grazing pressure on pastures by decreasing the nutrient requirements of cows. Calves that are weaned early are relatively efficient at converting feed to gain, and can weigh as much, or more than, calves allowed to remain with their dams until a conventional weaning age is reached. Balanced diets with excellent physical, chemical, and palatabi...
متن کاملEffects of early life adverse experiences on the brain: implications from maternal separation models in rodents
During postnatal development, adverse early life experiences affect the formation of neuronal networks and exert long-lasting effects on neural function. Many studies have shown that daily repeated maternal separation (MS), an animal model of early life stress, can regulate the hypothalamic-pituitary-adrenal axis (HPA axis) and affect subsequent brain function and behavior during adulthood. How...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2010
ISSN: 1471-2202
DOI: 10.1186/1471-2202-11-123